Recent Advances in Computational Prediction of Drug Absorption and Permeability in Drug Discovery
نویسندگان
چکیده
منابع مشابه
Recent advances in computational prediction of drug absorption and permeability in drug discovery.
Approximately 40%-60% of developing drugs failed during the clinical trials because of ADME/Tox deficiencies. Virtual screening should not be restricted to optimize binding affinity and improve selectivity; and the pharmacokinetic properties should also be included as important filters in virtual screening. Here, the current development in theoretical models to predict drug absorption-related p...
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ژورنال
عنوان ژورنال: Current Medicinal Chemistry
سال: 2006
ISSN: 0929-8673
DOI: 10.2174/092986706778201558